Used in bone metabolism studies to measure type I procollagen synthesis, serving as a biomarker for bone formation. Commonly applied in osteoporosis research and clinical trials to assess the efficacy of treatments targeting bone turnover. Enables researchers to monitor changes in collagen production in response to hormonal therapies, anti-resorptive drugs, or lifestyle interventions. Widely utilized in preclinical and clinical settings due to its high sensitivity and specificity for detecting early bone formation activity.