Used in bone metabolism research to measure C-terminal telopeptide of type I collagen, a biomarker for bone resorption. Helps assess osteoclast activity and monitor bone loss in conditions like osteoporosis. Commonly applied in preclinical studies and drug development to evaluate the effectiveness of anti-resorptive therapies such as bisphosphonates or denosumab. Provides quantitative data from serum or plasma samples, enabling researchers to track changes in bone turnover with high sensitivity and specificity.