2-(2,6-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
95%
Reagent
Code: #167199
CAS Number
1355011-22-1
blur_circular Chemical Specifications
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Molecular Information
Weight
254.08 g/mol
Formula
C₁₃H₁₇F₂O₂B
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Registry Numbers
MDL Number
MFCD22418271
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Physical Properties
Boiling Point
298.8±40.0 °C(Predicted)
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Storage & Handling
Density
1.10±0.1 g/cm3(Predicted)
Storage
Room temperature, inert gas
description Product Description
Used as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its boronate ester group facilitates efficient coupling with aryl halides under mild conditions, making it valuable in the preparation of complex organic molecules, particularly in drug discovery and development. The difluoro substitution enhances metabolic stability and binding affinity in bioactive compounds, while the methyl group aids in tuning electronic and steric properties. Commonly employed in late-stage functionalization to introduce aromatic fragments in medicinal chemistry campaigns.
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