Triethylammonium formate solution is widely used as a volatile buffer in liquid chromatography-mass spectrometry (LC-MS) applications. Its low molecular weight and high volatility make it an ideal choice for efficient ionization and minimal interference during analysis. It is particularly useful in the separation and detection of polar compounds, peptides, and small molecules. Additionally, it serves as a mobile phase additive to enhance the resolution and sensitivity of chromatographic separations. In organic synthesis, it acts as a mild and non-toxic reagent for formylation reactions and as a solvent or catalyst in various chemical transformations. Its compatibility with sensitive biological samples also makes it valuable in proteomics and metabolomics research.