Disodium glycerophosphate hydrate is widely used in the food and beverage industry as a nutrient supplement and stabilizer. It enhances the nutritional value of products by providing a source of phosphorus, which is essential for bone health and energy metabolism. In sports drinks and dietary supplements, it helps replenish electrolytes and supports muscle recovery. Additionally, it acts as a buffering agent, maintaining the pH balance in processed foods and beverages.

In the pharmaceutical sector, it is utilized in formulations for oral and injectable solutions, where it serves as a source of phosphate for patients with deficiencies. It is also found in skincare and personal care products, functioning as a moisturizing agent and improving skin hydration. Its ability to stabilize emulsions makes it valuable in creams, lotions, and other cosmetic formulations.