Used in molecular recognition and host-guest chemistry due to its large cavity, Calix[8]arene is effective in binding large ions and neutral molecules. It serves as a building block in supramolecular chemistry for designing sensors and selective extractants. Applied in separation processes, especially for metal ions and organic pollutants. Also explored in drug delivery systems for its ability to form stable complexes with bioactive molecules. Plays a role in nanotechnology and material science by enabling the assembly of functional nanostructures.