KN-92 is the inactive analog of KN-93, a selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). Primarily used in research as a negative control, it binds to CaMKII without inhibiting its activity, aiding studies of kinase signaling in cellular processes like proliferation, differentiation, and apoptosis. Researchers employ KN-92 to validate the specificity of active inhibitors (e.g., KN-93) in disease models such as cancer, inflammation, and neurodegenerative disorders. It serves as a reference compound in experiments and supports drug discovery by confirming on-target effects through comparison.