GTPL7939
99%
Reagent
Code: #62658
CAS Number
1224887-10-8
science Other reagents with same CAS 1224887-10-8
blur_circular Chemical Specifications
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Molecular Information
Weight
414.89 g/mol
Formula
C₂₀H₂₃ClN₆O₂
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Registry Numbers
MDL Number
MFCD30502650
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Storage & Handling
Storage
-20℃
description Product Description
GTPL7939 is a potent, reversible, cell-permeable, and selective allosteric inhibitor of PI3Kα (phosphoinositide 3-kinase α; IC50 = 1.3 nM), displaying >300-fold selectivity over other class I PI3K isoforms, mTOR, DNA-PK, and PI4Ks. This specialty research chemical is investigated in oncology for inhibiting proliferation of PI3Kα/PTEN-driven cancer cells, tumor growth, and metastasis. It is studied as a targeted therapy candidate and for synergy with chemotherapy to improve outcomes. Preclinical research assesses its pharmacokinetics, safety, and effects on cancer signaling pathways.
format_list_bulleted Product Specification
| Test Parameter | Specification |
|---|---|
| Appearance | White to Khaki Powder |
| Purity (%) | 98.5-100 |
| Infrared Spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
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