huCD38-HEK293 is not a chemical compound but rather refers to a biological system—specifically, human CD38 (huCD38) expressed in HEK293 cells, which are a commonly used human embryonic kidney cell line in research. This system is primarily used in biomedical research to study the function and regulation of the CD38 protein, which plays a key role in immune cell signaling, calcium metabolism, and the production of secondary messengers like cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). The huCD38-HEK293 expression system is widely applied in drug development, particularly for screening and evaluating therapeutic antibodies or small molecules targeting CD38. It is instrumental in the research of multiple myeloma and other hematologic malignancies, where CD38 is overexpressed and serves as a target for monoclonal antibody therapies such as daratumumab and isatuximab. The system allows for consistent and high-level expression of the human CD38 antigen, making it valuable for binding assays, functional assays, and cytotoxicity studies during antibody characterization. Additionally, huCD38-HEK293 cells are used to investigate CD38 enzymatic activity and its role in NAD+ metabolism, which has implications in aging, inflammation, and metabolic disorders. This cellular model supports target validation, pharmacokinetic studies, and the development of diagnostic tools aimed at CD38-related pathways.