Neriifolin is a cardiac glycoside primarily recognized for its applications in medical research, especially in the study of cardiovascular conditions. Derived from plants such as Thevetia peruviana, it influences cardiac function by modulating heart contractions and rhythm, positioning it as a key compound in developing treatments for cardiac disorders. Its cytotoxic properties have also been explored in cancer research, demonstrating potential to inhibit the proliferation of certain cancer cells, such as those in leukemia and other lines. While promising, neriifolin's use remains limited to laboratory and preclinical studies due to the need for further investigation into its efficacy, toxicity, and safety for clinical applications.