Used primarily in the treatment of chronic heart failure, it works by inhibiting the enzyme neprilysin, which helps to increase the levels of beneficial peptides in the body that promote vasodilation and reduce fluid retention. This action helps to improve heart function and reduce symptoms such as shortness of breath and fatigue. It is often combined with valsartan to enhance its effectiveness in managing heart failure. This combination has been shown to significantly reduce the risk of hospitalization and death in patients with reduced ejection fraction. It is administered orally and requires careful monitoring of kidney function and potassium levels to avoid potential side effects.