Zatebradine is primarily used in pharmacological research as a selective bradycardic agent. It works by inhibiting the funny current (I_f) in the sinus node of the heart, reducing the heart rate without significantly affecting other cardiac functions, making it a valuable tool in studying heart rate modulation and its effects on cardiovascular physiology. Researchers utilize it to explore the relationship between heart rate and myocardial oxygen demand, particularly in conditions like angina or heart failure. Additionally, it has been investigated for its potential therapeutic applications in managing ischemic heart disease by improving myocardial efficiency. Its role in experimental models helps in understanding the mechanisms of heart rate control and developing targeted therapies for cardiac disorders. It remains in the research stage, and further studies are required to confirm its safety and efficacy.