RGB-286638 free base is primarily utilized in research and development within the field of oncology. It functions as a potent inhibitor of cyclin-dependent kinases (CDKs), which are crucial in regulating cell cycle progression. By targeting these kinases, it has shown potential in halting the proliferation of cancer cells, particularly in studies focused on breast cancer, lung cancer, and other malignancies. Researchers are exploring its efficacy in combination therapies to enhance its anti-tumor effects. Additionally, it serves as a valuable tool in biochemical studies to better understand the mechanisms of CDK inhibition and its impact on cell cycle regulation. Its application extends to preclinical trials, where it is being evaluated for its pharmacokinetics, safety profile, and therapeutic potential in various cancer models.