Used primarily in the treatment of gallstones, especially in patients who cannot undergo surgery. It helps dissolve cholesterol-rich gallstones by reducing cholesterol secretion into bile and promoting bile flow. Also widely prescribed for primary biliary cholangitis (PBC), where it improves liver function tests and may delay disease progression. Commonly used in managing cholestatic liver diseases in children and adults, including intrahepatic cholestasis of pregnancy, to reduce itching and improve liver parameters. Investigated for non-alcoholic fatty liver disease (NAFLD) due to its protective effects on liver cells. Used in some countries to treat cystic fibrosis-related liver disease. Its mechanism includes stabilizing cell membranes, reducing apoptosis, and exerting anti-inflammatory effects in the liver.