Used primarily as an anticonvulsant in the treatment of epilepsy, particularly for partial seizures in adults. It is also prescribed as adjunctive therapy in managing seizures associated with Lennox-Gastaut syndrome. Beyond epilepsy, zonisamide has shown efficacy in the treatment of Parkinson’s disease, especially for reducing motor fluctuations and dyskinesia. It is being explored for use in neuropathic pain, migraine prophylaxis, and certain psychiatric conditions such as bipolar disorder and obesity due to its effects on neurotransmitter systems and metabolic rate. Its mechanism involves modulation of sodium and calcium channels, along with weak carbonic anhydrase inhibition, contributing to its broad neurological applications.