N,N,N',N'-Tetrabutylmalonamide is primarily used as a selective extractant in the separation and purification of metal ions, particularly in the nuclear fuel cycle. It is effective in extracting actinides, such as uranium and plutonium, from spent nuclear fuel or radioactive waste solutions. The compound’s ability to form stable complexes with specific metal ions makes it valuable in solvent extraction processes, aiding in the recovery and recycling of valuable materials while minimizing environmental impact. Additionally, it has been explored in research for its potential use in the separation of rare earth elements, which are critical for various high-tech applications. Its chemical stability and selectivity make it a useful reagent in both industrial and laboratory settings for metal ion recovery and purification.