Deferasirox (Fe3 chelate) is primarily used in the treatment of chronic iron overload caused by long-term blood transfusions, a condition often seen in patients with thalassemia, sickle cell anemia, and other transfusion-dependent anemias. It works by binding to excess iron in the body and promoting its excretion via feces, thereby reducing iron accumulation in tissues and organs. This helps prevent complications such as liver damage, heart problems, and endocrine disorders associated with iron overload. It is administered orally, making it a convenient option for long-term management. Additionally, it is sometimes used off-label for iron overload due to other conditions or treatments, such as myelodysplastic syndromes. Regular monitoring of liver and kidney function is essential during therapy due to potential side effects.