tert-Butyl (2S,4S)-4-((tert-butyldimethylsilyl)oxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate
97%
Reagent
Code: #141157
CAS Number
791602-93-2
blur_circular Chemical Specifications
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Molecular Information
Weight
331.52 g/mol
Formula
C₁₆H₃₃NO₄Si
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Registry Numbers
MDL Number
MFCD28403171
thermostat
Physical Properties
Boiling Point
373.4±27.0 °C(Predicted)
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Storage & Handling
Density
1.02±0.1 g/cm3(Predicted)
Storage
2-8°C, Inert Gas
description Product Description
Used as a protected intermediate in the synthesis of complex organic molecules, particularly in pharmaceuticals and natural products. The tert-butyldimethylsilyl (TBS) and tert-butyloxycarbonyl (Boc) groups serve as orthogonal protecting groups for alcohols and amines, respectively, allowing selective deprotection and functionalization during multi-step syntheses. The hydroxymethyl and pyrrolidine functionalities make it valuable in the construction of proline-based peptidomimetics and bioactive compounds targeting enzymes or receptors. Commonly employed in medicinal chemistry for developing protease inhibitors and other therapeutic agents where stereochemical control is critical.
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