1-(Trimethylsilyl)imidazole (TSIM)
For GC derivatization, 98.0%
- Product Code: 239942
Alias:
N-trimethylsilylimidazole
CAS:
18156-74-6
| Molecular Weight: | 140.26 g./mol | Molecular Formula: | C₆H₁₂N₂Si |
|---|---|---|---|
| EC Number: | 242-040-3 | MDL Number: | MFCD00005280 |
| Melting Point: | -42 °C | Boiling Point: | 93-94 °C/14 mm Hg(lit.) |
| Density: | 0.957 g/mL at 20 °C | Storage Condition: | 2~8°C |
Product Description:
Used as a silylating agent in organic synthesis, particularly for the protection of hydroxyl, carboxyl, and amino groups in sensitive molecules. Its reactivity makes it suitable for introducing the trimethylsilyl (TMS) group under mild conditions, which is useful in the preparation of intermediates for pharmaceuticals, agrochemicals, and fine chemicals. Commonly employed in nucleoside and steroid chemistry where selective protection is required. Also used in analytical chemistry for derivatization of polar compounds prior to gas chromatography to improve volatility and detection. Works efficiently in anhydrous environments and is often preferred for its relatively clean reaction profile and ease of removal of by-products.
Sizes / Availability / Pricing:
| Size | Availability | Price | Quantity |
|---|---|---|---|
| 5ml | 10-20 days | ฿680.00 |
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| 25ml | 10-20 days | ฿2,120.00 |
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| 100ml | 10-20 days | ฿5,780.00 |
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| 500ml | 10-20 days | ฿21,800.00 |
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| 2.5L | 10-20 days | ฿59,990.00 |
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1-(Trimethylsilyl)imidazole (TSIM)
Used as a silylating agent in organic synthesis, particularly for the protection of hydroxyl, carboxyl, and amino groups in sensitive molecules. Its reactivity makes it suitable for introducing the trimethylsilyl (TMS) group under mild conditions, which is useful in the preparation of intermediates for pharmaceuticals, agrochemicals, and fine chemicals. Commonly employed in nucleoside and steroid chemistry where selective protection is required. Also used in analytical chemistry for derivatization of polar compounds prior to gas chromatography to improve volatility and detection. Works efficiently in anhydrous environments and is often preferred for its relatively clean reaction profile and ease of removal of by-products.
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