Used primarily in organic synthesis, 3-Ethynylbenzenesulfonamide serves as a key intermediate in the development of pharmaceuticals and bioactive compounds. Its ethynyl group allows for versatile chemical reactions, such as click chemistry, enabling the creation of complex molecules with potential therapeutic applications. It is also employed in the study of enzyme inhibitors, particularly in targeting sulfonamide-binding proteins, which are relevant in treating diseases like cancer and bacterial infections. Additionally, its sulfonamide moiety contributes to its use in designing compounds with anti-inflammatory or antimicrobial properties.