4-Ethynylbenzamide is primarily utilized in organic synthesis and pharmaceutical research as a versatile building block. Its ethynyl group makes it a valuable intermediate in click chemistry, particularly in the formation of triazole compounds through copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. This property is exploited in drug discovery and development for creating complex molecular structures with potential biological activity. Additionally, it serves as a precursor in the synthesis of various heterocyclic compounds, which are often explored for their medicinal properties. Its application extends to materials science, where it is used in the development of functionalized polymers and advanced materials with specific electronic or mechanical properties.