Chromeazurol S is widely used as a metallochromic indicator in analytical chemistry, particularly in complexometric titrations. It is effective in detecting metal ions such as aluminum, iron, and rare earth elements due to its ability to form colored complexes with these metals. The compound is also utilized in spectrophotometric methods for determining trace amounts of metals in environmental and biological samples. Additionally, Chromeazurol S serves as a reagent in the study of metal-ligand interactions, aiding in the understanding of coordination chemistry. Its sensitivity to pH changes makes it valuable in pH-dependent analytical applications.