Used primarily in dermatology for its potent anti-inflammatory and immunosuppressive effects. Commonly formulated in topical creams and ointments to treat skin conditions such as eczema, psoriasis, and allergic dermatitis. The 17-propionate ester modification enhances skin penetration and prolongs local activity, making it effective at lower concentrations. Also used in some veterinary applications for treating inflammatory skin disorders in animals. Due to its high potency, it is typically prescribed for short-term use to minimize risk of skin atrophy and systemic absorption.