PyBOP is widely used in peptide synthesis as a coupling reagent, facilitating the formation of peptide bonds between amino acids. It is particularly effective in solid-phase peptide synthesis (SPPS), where it helps in the efficient and rapid assembly of peptide chains. Its high reactivity and low risk of racemization make it a preferred choice for synthesizing complex peptides and small proteins. Additionally, PyBOP is utilized in the preparation of amides, esters, and other carboxylic acid derivatives in organic synthesis. Its ability to work under mild conditions and produce high yields makes it valuable in pharmaceutical research and the production of bioactive compounds.