Tetramethyl 1,2,3,4-Cyclobutanetetracarboxylate is primarily used in organic synthesis as a versatile building block for creating complex molecular structures. Its cyclobutane ring and multiple ester groups make it valuable in the development of polymers and specialty chemicals. It is often employed in the synthesis of advanced materials, such as liquid crystals and photoresists, which are critical in electronics and display technologies. Additionally, it serves as a precursor in the production of pharmaceuticals, where its unique structure can be modified to create biologically active compounds. Its applications also extend to research and development, where it is utilized to study ring strain and reactivity in cyclobutane derivatives.