Sulfobutylether-β-cyclodextrin (SBE-β-CD) is a modified form of the cyclic oligosaccharide beta-cyclodextrin. It is widely used for several applications due to its unique properties. Here are some key points about the usage of SBE-β-CD:
Solubilization of poorly soluble drugs: SBE-β-CD can significantly improve the aqueous solubility of poorly water-soluble drugs by forming inclusion complexes with the drug molecules. This property is extensively exploited in the pharmaceutical industry to formulate drugs with low solubility.
Parenteral drug delivery: SBE-β-CD is relatively non-toxic and can be administered intravenously or intramuscularly. It is used as a solubilizing agent for parenteral formulations of drugs with low solubility.
Stabilization of drugs: SBE-β-CD can protect drugs from degradation by encapsulating them within its hydrophobic cavity, shielding them from factors like light, oxidation, and hydrolysis.
Masking bitter taste: SBE-β-CD can form inclusion complexes with bitter-tasting drugs, masking their unpleasant taste, which is beneficial for oral formulations.
Enzyme immobilization: SBE-β-CD can be used as a support material for immobilizing enzymes, improving their stability and allowing their reuse in various industrial processes.
Analytical chemistry: SBE-β-CD is used in analytical techniques like capillary electrophoresis and chromatography for separating and analyzing various compounds.
Environmental remediation: SBE-β-CD can form inclusion complexes with environmental pollutants like polycyclic aromatic hydrocarbons and organochlorine pesticides, aiding in their removal from contaminated sites.
