Piroxicam-β-cyclodextrin is primarily used in the pharmaceutical industry to enhance the solubility and bioavailability of piroxicam, a nonsteroidal anti-inflammatory drug (NSAID). This complex is particularly beneficial in oral and topical formulations, where it helps improve the drug's absorption and therapeutic efficacy.

In oral applications, it is commonly used to treat conditions like osteoarthritis, rheumatoid arthritis, and other inflammatory disorders by providing faster onset of action and reduced gastrointestinal irritation compared to plain piroxicam.

For topical use, it is formulated into gels or creams to alleviate localized pain and inflammation, such as in musculoskeletal injuries or joint pain, offering targeted delivery with minimal systemic side effects.

Additionally, the β-cyclodextrin component stabilizes piroxicam, extending its shelf life and making it more suitable for various drug delivery systems. This combination is particularly advantageous for patients who require long-term anti-inflammatory therapy with improved tolerability.