Arteannuin N is primarily investigated for its potential antimalarial properties, showing activity against Plasmodium species, including strains resistant to conventional drugs like chloroquine. It contributes to the broader class of sesquiterpene lactones derived from Artemisia annua, which are studied for synergistic effects in combination therapies. Research also explores its anti-inflammatory and anticancer activities, particularly in inhibiting tumor cell proliferation and modulating immune responses. Due to its structural similarity to artemisinin, it serves as a lead compound in developing novel derivatives with enhanced bioavailability and therapeutic efficacy. Its applications remain largely in the preclinical research phase, focusing on drug development and pharmacological screening.