6-Aminonicotinamide is primarily used in research settings to study cellular metabolism and stress responses. It acts as an inhibitor of the pentose phosphate pathway, which is crucial for generating NADPH and ribose-5-phosphate. By blocking this pathway, it helps researchers investigate the effects of oxidative stress on cells and tissues. This compound is also utilized in cancer research to explore its potential in sensitizing cancer cells to radiation and chemotherapy, as it disrupts the metabolic processes that cancer cells rely on for survival. Additionally, 6-Aminonicotinamide is employed in studies related to neurodegenerative diseases to understand the role of metabolic dysfunction in neuronal cell death. Its ability to induce metabolic stress makes it a valuable tool in experimental biology and pharmacology.