PAMAM dendrimers with an ethylenediamine core, particularly Generation 2.0, are widely used in drug delivery systems due to their highly branched, tree-like structure. This structure allows for efficient encapsulation of therapeutic agents, enhancing drug solubility and targeted delivery to specific cells or tissues. They are also employed in gene therapy as non-viral vectors for transporting DNA or RNA into cells, improving transfection efficiency while minimizing toxicity. In addition, these dendrimers find applications in diagnostic imaging, where they act as carriers for contrast agents, improving imaging precision in medical diagnostics. Their surface functionality can be modified to attach specific ligands, enabling targeted delivery in cancer therapy. Furthermore, they are used in material science for creating nanocomposites and coatings, leveraging their nanoscale size and surface properties for advanced material design.