PAMAM-OH dendrimers are widely used in drug delivery systems due to their ability to encapsulate and transport therapeutic agents. Their highly branched structure and surface hydroxyl groups enable efficient loading of drugs, ensuring targeted delivery and controlled release. In gene therapy, they serve as non-viral vectors for delivering nucleic acids, enhancing transfection efficiency while minimizing toxicity.

In biomedical applications, these dendrimers are utilized in imaging and diagnostics. They can be functionalized with contrast agents, improving the resolution and accuracy of imaging techniques like MRI. Additionally, their biocompatibility makes them suitable for use in tissue engineering, where they promote cell adhesion and growth.

In industrial settings, PAMAM-OH dendrimers are employed in catalysis, where their large surface area and functional groups facilitate efficient chemical reactions. They are also used in environmental applications, such as water purification, where they help remove contaminants through adsorption and complexation.

Overall, PAMAM-OH dendrimers are versatile materials with significant applications in healthcare, industry, and environmental science.