Tradipitant is primarily used in the treatment of chronic pruritus, a condition characterized by persistent itching that can significantly impact quality of life. It works by selectively inhibiting the neurokinin-1 (NK-1) receptor, which is involved in the transmission of itch signals in the nervous system. This makes it particularly effective for conditions like atopic dermatitis and other forms of chronic itching where traditional treatments may not provide sufficient relief.

Additionally, Tradipitant has been explored for its potential in managing nausea and vomiting, especially in cases related to chemotherapy-induced nausea and postoperative recovery. Its ability to block the NK-1 receptor helps in reducing these symptoms by interfering with the pathways that trigger them.

Research is also ongoing to evaluate its efficacy in addressing anxiety and sleep disorders, as the NK-1 receptor is implicated in stress responses and emotional regulation. This broadens its potential therapeutic applications beyond its initial focus on pruritus and nausea.