Trifarotene is primarily used in dermatology for the treatment of acne vulgaris, specifically targeting facial and truncal acne. It is applied topically as a cream and works by normalizing skin cell turnover and reducing inflammation, which helps to prevent the formation of new acne lesions. Its selective action on retinoic acid receptors in the skin makes it effective while minimizing systemic side effects. It is often prescribed for patients who have not responded well to other acne treatments, offering a targeted approach to managing persistent or moderate-to-severe acne. Regular use can improve skin texture and reduce the appearance of acne scars over time.