IU1 is primarily used in biochemical research as a selective inhibitor of the deubiquitinating enzyme USP14. This enzyme plays a significant role in the ubiquitin-proteasome system, which is crucial for protein degradation and regulation within cells. By inhibiting USP14, IU1 helps researchers study the effects of impaired protein degradation, which can provide insights into various diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's. Additionally, IU1 is utilized in cancer research to explore the role of USP14 in tumor progression and its potential as a therapeutic target. Its application extends to understanding cellular stress responses and the mechanisms of protein homeostasis, making it a valuable tool in molecular biology and pharmacology studies.