Oleamide MEA (85% Powder)

Analytical Code: 253045

Oleoyl‑ethanolamide (OEA) food‑grade powder; typical 125 mg BID with RCT support for appetite/weight and oxidative‑stress markers.

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Oleamide MEA (85% Powder)

Oleoyl‑ethanolamide (OEA) food‑grade powder; typical 125 mg BID with RCT support for appetite/weight and oxidative‑stress markers.

oleoyl‑ethanolamide (OEA) — the monoethanolamide of oleic acid. That’s different from oleamide (simple amide; animal sleep lipid)


Benefit Typical study dose* Key human findings High-quality sources
Appetite & weight 250 mg/day (125 mg BID), 8 weeks ↓ hunger, body weight, BMI, waist; ↑ PPAR‑α expression vs placebo. PubMed
Oxidative stress 200–300 mg/day, 8–12 weeks ↑ TAC, SOD; ↓ MDA, ox‑LDL. Cytokines mixed across trials. Frontiers 2023
Lipids & glycemia 250–300 mg/day, 8–12 weeks Signals for ↓ triglycerides and improved fasting glucose/HOMA‑IR (pooled analyses, needs more RCTs). BMC 2024, Frontiers 2025

*Common study pattern: ≥250 mg/day for ≥8 weeks.



Mechanistic highlights

  1. PPAR‑α agonist: Gut‑derived lipid produced during fat absorption; promotes satiety and fat utilization.
  2. Vagal signaling: Intestinal OEA signals to the brain to extend inter‑meal intervals.
  3. Metabolic effects: Influences lipid handling and oxidative‑stress pathways in human studies.


Safety & practical use

  • Usual supplemental range: 125–300 mg/day (often 125 mg BID).
  • Evidence grade: Moderate and evolving; best data for appetite/weight, oxidative‑stress markers.
  • Interactions/medical advice: Advise oversight for pregnancy, chronic disease, or when on lipid/glucose‑active medication.
  • Storage: Cool, dry, sealed; protect from light/moisture. Micro limits per COA.
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