Oleamide MEA (85% Powder)
Analytical
Code: 253045
Oleoyl‑ethanolamide (OEA) food‑grade powder; typical 125 mg BID with RCT support for appetite/weight and oxidative‑stress markers.
oleoyl‑ethanolamide (OEA) — the monoethanolamide of oleic acid. That’s different from oleamide (simple amide; animal sleep lipid)
| Benefit | Typical study dose* | Key human findings | High-quality sources |
|---|---|---|---|
| Appetite & weight | 250 mg/day (125 mg BID), 8 weeks | ↓ hunger, body weight, BMI, waist; ↑ PPAR‑α expression vs placebo. | PubMed |
| Oxidative stress | 200–300 mg/day, 8–12 weeks | ↑ TAC, SOD; ↓ MDA, ox‑LDL. Cytokines mixed across trials. | Frontiers 2023 |
| Lipids & glycemia | 250–300 mg/day, 8–12 weeks | Signals for ↓ triglycerides and improved fasting glucose/HOMA‑IR (pooled analyses, needs more RCTs). | BMC 2024, Frontiers 2025 |
*Common study pattern: ≥250 mg/day for ≥8 weeks.
Mechanistic highlights
- PPAR‑α agonist: Gut‑derived lipid produced during fat absorption; promotes satiety and fat utilization.
- Vagal signaling: Intestinal OEA signals to the brain to extend inter‑meal intervals.
- Metabolic effects: Influences lipid handling and oxidative‑stress pathways in human studies.
Safety & practical use
- Usual supplemental range: 125–300 mg/day (often 125 mg BID).
- Evidence grade: Moderate and evolving; best data for appetite/weight, oxidative‑stress markers.
- Interactions/medical advice: Advise oversight for pregnancy, chronic disease, or when on lipid/glucose‑active medication.
- Storage: Cool, dry, sealed; protect from light/moisture. Micro limits per COA.
- White to pale yellowish fine powder
- Cool (15-25C)
- 24 Months from manufacturing or testing date.
- 125mg - 500mg
- 250mg
- 125mg - 500mg
- 250mg
- Powder mixing for food/beverage (oil‑phase disperse or glycol premix)
- Heat Tolerant
- 0.00 - 0.00
- Soluble in Water, Dispersible in water
- -
| Test Name | Specification |
|---|---|
| Appearance | White to pale yellowish fine powder |
| Granularity | 80 mesh |
| Content | ≥85% (HPLC) |
| Odor & Taste | Special Sour |
| Loss on drying | ≤5.0% |
| Heavy metal ppm | ≤10 |
| Lead (ppm) | ≤1.0 |
| Arsenic (ppm) | ≤1.50 |
| Ash Content | ≤5.0% |
| Total Bacteria | ≤1000 cfu/g |
| Yeast Mold | ≤100 cfu/g |
| Salmonella | Negative |
| E.Coli | Negative |
| Pesticides residues | Meet the RS |
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