(Bromodifluoromethyl)triphenylphosphonium Bromide
≥95%
science Other reagents with same CAS 58201-66-4
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description Product Description
Used as a reagent in organic synthesis for the introduction of the bromodifluoromethyl group (–CF2Br) into organic molecules. This transformation is valuable in the preparation of fluorinated compounds that serve as intermediates in pharmaceuticals, agrochemicals, and materials science. The phosphonium salt facilitates the formation of difluorocarbene or related species under basic conditions, enabling efficient C–H difluoromethylation or cyclopropanation reactions. Its utility in generating fluorinated building blocks makes it particularly important in medicinal chemistry for modulating the metabolic stability, lipophilicity, and bioavailability of drug candidates.
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