(Bromodifluoromethyl)triphenylphosphonium Bromide
≥95%
Reagent
Code: #154925
CAS Number
58201-66-4
blur_circular Chemical Specifications
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Molecular Information
Weight
472.1 g/mol
Formula
C₁₉H₁₅Br₂F₂P
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Registry Numbers
MDL Number
MFCD00191843
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Storage & Handling
Storage
2-8°C, light-proof, inert gas
description Product Description
Used as a reagent in organic synthesis for the introduction of the bromodifluoromethyl group (–CF2Br) into organic molecules. This transformation is valuable in the preparation of fluorinated compounds that serve as intermediates in pharmaceuticals, agrochemicals, and materials science. The phosphonium salt facilitates the formation of difluorocarbene or related species under basic conditions, enabling efficient C–H difluoromethylation or cyclopropanation reactions. Its utility in generating fluorinated building blocks makes it particularly important in medicinal chemistry for modulating the metabolic stability, lipophilicity, and bioavailability of drug candidates.
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