LY 345899 is primarily explored for its potential in neurological research, particularly in studying conditions related to dopamine and serotonin systems. It acts as a selective antagonist, making it useful for investigating the roles of specific receptor subtypes in brain function and behavior. Researchers utilize it to better understand the mechanisms underlying psychiatric disorders, such as schizophrenia and depression, and to evaluate potential therapeutic targets. Its application in preclinical studies helps in the development of novel drugs targeting these receptor systems.