SB-277011 is primarily used in research settings to study the role of dopamine receptors in the brain. It is a selective antagonist for the dopamine D3 receptor, making it a valuable tool for investigating the function of these receptors in various neurological and psychiatric conditions. Researchers utilize SB-277011 to explore its potential effects on addiction, particularly in relation to drugs of abuse, as D3 receptors are thought to play a role in reward and reinforcement pathways. Additionally, it is employed in studies examining its impact on cognitive functions, mood disorders, and Parkinson's disease, providing insights into the therapeutic potential of targeting D3 receptors. Its selectivity allows for a clearer understanding of D3 receptor-specific mechanisms without significant interference from other dopamine receptor subtypes.