Omarigliptin is primarily used in the management of type 2 diabetes mellitus. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which helps regulate blood sugar levels by enhancing the body's ability to release insulin after meals and reducing the amount of glucose produced by the liver. Due to its once-weekly dosing regimen, it offers a convenient treatment option for patients, improving adherence to medication. It is often prescribed as part of a comprehensive diabetes management plan that includes diet, exercise, and other medications. Its efficacy in lowering HbA1c levels makes it a valuable tool in long-term glycemic control. Additionally, it is generally well-tolerated, with a lower risk of hypoglycemia compared to some other diabetes treatments.