2-Ethylhexyl oleate is widely used as an emollient in personal care and cosmetic products. It helps to soften and smooth the skin, making it a common ingredient in lotions, creams, and moisturizers. Its lightweight and non-greasy texture make it suitable for use in sunscreens, makeup, and hair care products, where it enhances spreadability and provides a silky feel.

In industrial applications, it serves as a lubricant and plasticizer, improving the flexibility and durability of materials like plastics, rubber, and coatings. Its compatibility with various polymers makes it useful in manufacturing processes. Additionally, it is employed in the formulation of metalworking fluids, where it acts as a lubricant to reduce friction and wear during machining operations. In the textile industry, it is used as a fiber coating agent to increase softness and reduce friction during production.

Its biodegradability and low toxicity also make it an environmentally friendly choice in many applications.