LH-21 is primarily explored for its potential in medical research, particularly in the study of cannabinoid receptors. It acts as a selective antagonist for the CB1 receptor, which makes it a valuable tool in understanding the endocannabinoid system. Researchers use LH-21 to investigate the role of CB1 receptors in various physiological processes, including appetite regulation, metabolism, and pain management. Its application in preclinical studies helps in developing therapeutic strategies for conditions like obesity, metabolic syndrome, and neuropathic pain. Additionally, LH-21 is utilized to study the effects of cannabinoid receptor modulation on the central nervous system, contributing to advancements in neurology and pharmacology.