RG-12525 is primarily utilized in the field of medical research, particularly in the study of cardiovascular diseases. It is known for its role as a selective endothelin receptor antagonist, which helps in understanding the mechanisms of vascular constriction and hypertension. Researchers use this compound to investigate potential therapeutic interventions for conditions like pulmonary arterial hypertension and chronic heart failure. Its application in experimental models aids in the development of drugs that target endothelin pathways, offering insights into improving cardiovascular health and managing related disorders.