SB408124
99%
Reagent
Code: #102499
CAS Number
288150-92-5
blur_circular Chemical Specifications
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Molecular Information
Weight
356.37 g/mol
Formula
C₁₉H₁₈F₂N₄O
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Registry Numbers
MDL Number
MFCD06411575
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Storage & Handling
Storage
-20℃
description Product Description
SB408124 is a selective non-peptide antagonist of the orexin-2 (OX2) receptor (pKi = 7.9), with much lower affinity for the orexin-1 (OX1) receptor. It is primarily used in research to investigate the orexin system's role in regulating sleep-wake cycles, arousal, feeding behavior, and stress responses. This compound serves as a valuable tool in pharmacological studies exploring potential therapies for disorders such as narcolepsy, insomnia, obesity, and addiction. Applications include in vitro receptor binding assays, functional studies on G-protein coupled receptor signaling, and in vivo models assessing effects on locomotor activity, sleep architecture, and metabolic processes.
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