Used in neuroscience and pharmaceutical research to measure the activity of CYP46 enzyme in mouse models, particularly in studies related to brain cholesterol metabolism. Helps investigate neurodegenerative diseases such as Alzheimer's, where cholesterol homeostasis in the brain plays a critical role. Enables researchers to evaluate the effects of drugs or genetic modifications on CYP46 activity, supporting the development of therapies targeting cholesterol elimination from the central nervous system.