Used in neuroscience and Alzheimer’s disease research to quantify γ-secretase activity in cell or tissue samples. Enables researchers to measure the levels of amyloid-beta peptides produced by γ-secretase cleavage of APP, helping evaluate drug candidates that modulate enzyme activity. Widely applied in preclinical studies to assess the efficacy and safety of γ-secretase inhibitors or modulators. Supports investigation into Notch signaling pathways, as γ-secretase also processes Notch receptors, making it valuable in cancer and developmental biology research. Provides a sensitive and specific method for high-throughput screening in drug discovery.