ST-836 hydrochloride is a potent and selective inhibitor of histone deacetylase 6 (HDAC6), a key enzyme involved in regulating protein acetylation, particularly tubulin. It is primarily utilized in research settings, especially in pharmacology, neuroscience, and immunology. By selectively inhibiting HDAC6, it facilitates the study of cellular processes such as microtubule dynamics, autophagy, and inflammatory signaling pathways. Researchers use it to explore its neuroprotective effects, anti-inflammatory properties, and potential in modulating pain pathways, with applications in models of neurological disorders like Alzheimer's disease, peripheral neuropathy, and immune-related conditions. Its specificity makes it a valuable tool in drug discovery for developing targeted therapies against HDAC6 dysregulation.