GGTI 298 TFA salt is primarily used in biochemical research to study the role of geranylgeranyltransferase I (GGTase I) in cellular processes. It acts as a selective inhibitor of GGTase I, an enzyme responsible for the post-translational modification of proteins by adding geranylgeranyl groups. This modification is crucial for the proper localization and function of certain proteins, particularly those involved in cell signaling pathways.

By inhibiting GGTase I, GGTI 298 TFA salt helps researchers investigate the effects of disrupted protein prenylation on cellular functions, such as cell proliferation, differentiation, and survival. It is particularly useful in studying the role of GGTase I in cancer biology, as aberrant protein prenylation is often linked to tumor growth and metastasis. Additionally, this compound is employed in studies related to cardiovascular diseases, immune responses, and neurodegenerative disorders, where GGTase I activity may play a significant role.

Its application in these areas provides valuable insights into the molecular mechanisms underlying various diseases and aids in the development of potential therapeutic strategies targeting protein prenylation pathways.