ML240 is a selective inhibitor of the AAA-ATPase p97, a protein involved in various cellular processes such as endoplasmic reticulum-associated degradation (ERAD), autophagy, and DNA damage response. Its application is primarily in research settings, where it is used to study the role of p97 in cellular mechanisms and disease pathways. By inhibiting p97, ML240 helps researchers understand its function in protein homeostasis and its potential as a therapeutic target in diseases like cancer, neurodegenerative disorders, and viral infections. Additionally, ML240 is utilized in drug discovery to explore the development of p97 inhibitors for clinical use, particularly in cancers where p97 is overexpressed or dysregulated. Its ability to disrupt protein degradation pathways makes it a valuable tool for investigating novel treatment strategies.