PGS-IN-1 is primarily utilized in research settings as a potent and selective inhibitor of phosphoglycerate synthase (PGS). This enzyme plays a critical role in glycolysis, the metabolic pathway that converts glucose into energy. By inhibiting PGS, researchers can study the effects of disrupted glycolysis in various biological systems, providing insights into cellular metabolism and energy production. This compound is particularly valuable in cancer research, as cancer cells often rely heavily on glycolysis for their rapid growth and proliferation. Inhibiting PGS can help scientists understand the metabolic vulnerabilities of cancer cells and explore potential therapeutic strategies. Additionally, PGS-IN-1 is used in biochemical studies to investigate the role of PGS in other metabolic disorders and diseases associated with altered energy metabolism. Its application extends to drug discovery, where it serves as a tool to validate PGS as a target for developing new treatments.