Used in molecular biology research to degrade DNA in acidic conditions, particularly useful in removing DNA from RNA preparations to prevent contamination. Commonly applied in protocols requiring selective DNA digestion without affecting RNA, such as in RNA isolation and purification. Also employed in studies of apoptosis, where fragmented DNA needs to be analyzed or removed. Its acid-dependent activity makes it suitable for use in lysosomal digestion systems and cellular degradation pathway studies. Frequently used in combination with other enzymes to achieve selective nucleic acid removal in complex biological samples.